If you find the idea of trying to determine the area and position of frames a bit daunting, or if you'd like to create fancy borders around your frames, but find it too tricky to do in LATEX, you may prefer to use a graphical user interface (GUI) to construct the frames, and possibly draw in the borders, and add colour to the backgrounds. The JpgfDraw application can be used for this purpose. Although principally designed as a graphics application, you can also use it to create a LATEX2e package based on the flowfram package. JpgfDraw's user manual has a step-by-step example that creates a poster.
If you are put off using a GUI because you find it difficult to use a mouse, the latest version of JpgfDraw provides keyboard alternatives. You will need to type in all the co-ordinates, but you can instantly see the effects.